- Fracture callus
- Stress fracture
- Osteoid osteoma
- Fibrous dysplasia
- Histiocytosis X
- Ewing's sarcoma
- Adamantinoma (tibia and, rarely, ulna or fibula)
- History, blood work, and C-reactive protein level plus cross-sectional imaging to search for sequestrum are useful in diagnosing infection.
- Use fine cut CT images, if necessary, to find the nidus of osteoid osteoma.
- Early stress fracture can be demonstrated by MRI and bone scan.
- Multiple bone involvement, deformities, and ground glass appearance suggest fibrous dysplasia.
- The presence of a soft tissue mass is typical of osteosarcoma, Ewing's sarcoma, and lymphoma.
Other Differential Diagnoses by Anatomic Location