Pressure on peripheral nerves can cause numbness, weakness or pain —compression neuropathy–in the areas the nerves supply. Pressure on the median nerve at the wrist (ie,  carpal tunnel syndrome) is the most common compression neuropathy of the upper extremity but compression of the ulnar, radial, posterior interosseous and  anterior interosseous nerves is also seen. Among these, compression of the ulnar nerve in the cubital tunnel at the elbow is the more common. The diagnosis of compression neuropathy is made by clinical correlation of the patient’s complaints with the anatomic distribution of the nerve, and may be confirmed by electro-diagnostic studies.

Structure and function

Within a peripheral nerve, axons are surrounded by endoneurium (shown in black in the figure below). A group of such axons are then surrounded by perineurium (shown in blue); these groups are called a fascicle. A collection of fascicles may be in turn bundled together with  blood vessels (red) within yet another sheath known as the epineurium (shown in green). The blood vessels then penetrate into the perineurium.

Figure: the anatomy of a nerve, showing endoneurium (black) around the axons composing the fascicle, in turn  surrounded by perineurium (shown in blue) and then epineurium (shown in green). (modified from wikipedia:

Mild nerve compression produces a reduction in epineural blood flow.  Prolonged compression can then reduce endoneural blood flow and produce ischemia.  Ischemia leads to breakdown of the blood–nerve barrier. Antigens released within the perineurial space then can incite an inflammatory response.


Eventually, scar tissue may form, and in turn irreversible damage to the nerve may result.

When patients with compression neuropathy undergo surgical decompression, the compressed nerve often is indented at the point of compression. Synovitis, sclerosis, fibrous hypertrophy, and edema of the synovium are also seen. 

The individual nerves each have their own so-called “sensory domain”, that is, area of skin whose sensation is provided (exclusively) by that peripheral nerve. As such, a sensory examination (or related complaints) can help hone the diagnosis.

Figure: The sensory domain of the radial nerve shown in yellow. Modified from wikipedia

Figure: The sensory domain of the median nerve shown in green. Modified from wikipedia

Figure: The sensory domains of the ulnar nerve shown in red. Modified  from wikipedia

The nerves to the hand also have unique motor function. For example, the radial nerve supplies the muscles that extend the wrist; thus, radial nerve dysfunction leads to a wrist drop. (Other examples are detailed below.)

Cubital tunnel syndrome (ulnar nerve compression near the elbow) may be caused by the presence of an accessory muscle, the anconeous epitrochlearis. This muscle, present in about 1/4 of the population, can become edematous and press on the nerve. 

Cubital tunnel syndrome may be aggravated by or associated with prolonged periods of flexing the elbow, such as during sleep or holding a phone while working at a desk. 

Radial nerve compression may arise from prolonged pressure on the nerve from the surrounding muscles in the proximal forearm area, or from direct pressure to the posterior aspect of the arm. This direct pressure mechanism is seen in patients who fall sleep on their arms; when it is another person’s body that exerted the pressure, the condition is known as “honeymoon palsy”.

Compression of the ulnar nerve in Guyon’s canal can be found with a fracture of the hamate bone or aneurysmal swelling of the ulnar artery. Compression of the ulnar nerve at the wrist is also seen in avid bicyclists, who may rest their wrists against their handlebars.  The most common cause of ulnar nerve compression at Guyon’s canal is a ganglion.

Figure: The approximate surface landmarks of Guyon’s canal are shown in red, through which the ulnar nerve (black) passes.


Patient presentation  

Compression neuropathy presents as numbness, weakness, pain, or  a mixture thereof.   The symptoms produced depend on which nerve is involved, where along the nerve it is being compressed, and the severity of the condition.

Ulnar nerve

Common symptoms of cubital tunnel syndrome, a compression neuropathy of the ulnar nerve at the elbow, are numbness of the small finger, and ulnar half of the ring finger.  There may be associated complaints of hand weakness or muscle wasting (causing visible deformity of the hand).   

Figure: Wartenberg’s sign is found when a patient’s small finger remains ABducted despite an instruction “bring all of your fingers together”. The finger may even rest in this position, as the extensor tendons pass slightly ulnar to the midpoint of the finger and thus exert a slight abduction force. If the ulnar nerve is dysfunctional, the extensors innervated by the radial nerve will overpower the intrinsic adductor muscle innervated by the ulnar nerve and the finger will “escape” as shown.

Figure: more subtle weakness of adduction can be demonstrated by asking the patient to hold a piece of paper between the ring  and small fingers (by adducting them, as shown by the red arrows in the top photo. If the ulnar nerve is dysfunctional, the force of adduction, though sufficient to bring the fingers closer together than what is seen with frank paralysis, will not be able to hold on to the paper, as shown in the bottom photo.

When compression of the ulnar nerve occurs more distally around the wrist and hand (ie within Guyon’s canal), patients report altered sensation on the palmar surfaces of the small and ring fingers but have normal sensation on the dorsum of the hand. There may also be weakness of the intrinsic muscles of the hand.

Radial nerve

The radial nerve runs along the humerus, and compression in the posterior aspect of the upper arm may produce weakness in wrist extension (causing a so-called ‘wrist drop’), weakness in finger extension (including the thumb),  and decreased sensation along the dorsum of the hand.  If the pressure on the nerve is more distal in the proximal forearm, there may be soreness in the mobile wad area of the proximal forearm and the posterior interosseous nerve alone is affected.  The main weakness is of finger and thumb extension; wrist extension will be relatively spared and there are no sensory changes.

Figure: Radial nerve dysfunction can produce a  “wrist drop”.


Anterior interosseous nerve

When compression involves the anterior interosseous nerve (running in the forearm opposite the posterior interosseous nerve), there is paralysis or weakness of the flexor pollicis longus, the flexor digitorum profundus to the index and long fingers and the and pronator quadratus. Compression of the anterior interosseous nerve produces no sensory loss. An affected patient attempting to make an “OK” sign would instead form a triangle, a shown:

FIGURE: This figure shows intact anterior interosseous nerve function. When the patient is asked to make an “OK sign”, there is flexion present at the thumb IP joint and index finger DIP joint.

Figure:  When the anterior interosseous nerve does not work normally, there is weakness of flexor pollicis longus and flexor digitorum profundus to the index and long fingers producing an absence of  flexion  at the thumb IP joint and index finger DIP joint when trying to make an “OK sign”.



The incidence of cubital tunnel has been measured in one study to about one in 5,000 (PMID: 15993135). (The incidence for the other peripheral neuropathies is known to be lower, but albeit imprecisely so. Note that mild forms of compression neuropathy will not be reported, as such patients will not present for care.

Differential diagnosis

The differential diagnosis of compression neuropathy can be categorized into three main areas:

  1. Diseases with dysfunction of the peripheral nerve, but not because of compression. Amyotrophic lateral sclerosis, multiple sclerosis, leprosy (Hansen’s disease is the eponym for infection of the nerves by mycobacterium leprae), Parsonage-Turner syndrome (viral infectious neuritis), and brachial neuritis — all fairly rare conditions — can cause peripheral nerve dysfunction.
  2. Cervical radiculopathy. Note that single level compression of one root often produces no gross weakness, and the symptoms would respect the dermatomal border of that nerve root, and not that of the peripheral nerve.
  3. Local musculoskeletal pathology. For instance, arthritis of the base of the thumb can cause localized pain on the radial side of the hand, or bony spurs arising from the edge of joints may cause mechanical rupture of adjacent tendons. (Note: local musculoskeletal conditions that mimic neuropathies should have no associated sensory deficit.)

Distinguishing a cervical radiculopathy from a compression neuropathy may be difficult. As shown, the differences between sensory areas are subtle. The main distinction is that the sensory symptoms of a compression neuropathy typically are located more distally, in the hand only. Also, the weakness tends to be less severe in cases  of ervical radiculopathy, as the affected muscle has input from other cervical levels. (This of course gets confusing when multiple cervical levels are involved, as may be the case.) Focal neck complaints may be the main distinguishing feature of ervical rather than extremity disease.

FIGURES: The close resemblance between the sensory distribution of the C8 nerve root and that of the ulnar nerve is shown. The “textbook” distinction, namely, that the ulnar nerve supplies only the ulnar side of the ring finger, is not reliable enough for clinical use. 

Red flags

Generalized complaints, involvement of multiple extremities and central or cranial nerve disturbances are all worrisome and suggest a diagnosis beyond a compression neuropathy.  Tongue fasciculations, visual changes, altered gait and a sense of imbalance in particular suggest neurologic disease. 

Objective evidence

Plain x-rays may be used to detect underlying anatomic abnormalities such as bony spurs or fracture fragments that may be a source of compression.

Magnetic resonance imaging may identify tumors or cysts that can compress nearby nerves.  MRI is frequently indicated to evaluate for a mass in ulnar nerve compression at Guyon’s canal.

Electrodiagnostic tests —  nerve conduction studies and electromyelography — can test the function of specific nerves.   Because there is a fairly high prevalence of abnormal results on nerve conduction studies and electromyelography (both false positives and false negatives), these tests are best considered as tools as an adjunct to physical examination, but not for screening purposes.

Treatment options and outcomes

Logically, the treatment of a compression neuropathy should be the decompression of the nerve. Nonetheless, a non-operative approach centering on modification of activity  may be sufficient, as the compression may have indeed been produced from overuse. Also, some patients may improve spontaneously or learn to tolerate their symptoms (if mild).

At times, splinting the wrist or elbow can minimize the pressure on the nerve. Better still, offending activities should be stopped. For example, avoiding riding a bicycle or hyperflexing the elbow may completely relieve compression of the ulnar nerve at the wrist and elbow respectively.  

When the symptoms of compression do not abate with non-operative treatment,  surgical decompression may be indicated.  Surgical decompression is effective when there is ischemia caused by pressure (ie when the diagnosis is correct) and the nerve has not been irreversibly damaged (and the diagnosis is timely). 


Risk factors and prevention

Mechanical risk factors for compression of the ulnar nerve at the elbow include a supracondylar (distal humerus) fracture in childhood, causing a so called “tardy” (or late-appearing) ulnar nerve palsy and chronic valgus stress, as from pitching in baseball.




Because many patients with a compression neuropathy are apt to get better spontaneously, there are probably many patients who, having tried a non-traditional approach to treatment, will credit this treatment for their (truly spontaneous) recovery. Even “traditional treatments” may benefit from this line of thinking: eg, the beneficial effect of local injections may be on the basis of a placebo effect. In general, any treatment that “amuses the patient while nature takes its course”, as Voltaire put it, may be reasonable as long as it does not put the patient at risk. In that regard, patients with nerve ischemia may progress from a state of reversible neuropathy to one of permanent damage; and thus not always is a “watch-and-wait” approach risk-free. 

The use of poor-fitted crutches  can lead to a compression neurorapthy of the axillary nerve: crutches that are too long can press into the axilla.

As noted, the term “honeymoon palsy” refers to a compression neuropathy (typically of the radial nerve) that results from excessive pressure on the arm from one’s bed mate. Cheiralgia paresthetica is the name for sensory abnormalities in the radial nerve distribution from tight handcuffs or other causes.

Key terms

Cubital tunnel syndrome; wrist drop; Guyon’s canal

Skills and competencies

  • Recognize the findings on history that are particular to lesions of the radial, median and ulnar nerves versus generalized conditions that may be neurologic or rheumatologic in nature but may mimic upper extremity compression syndromes.   
  • Perform physical examination maneuvers that assess the radial, median and ulnar nerves.