2002 OITE Question 37

Question

Which of the following is an effect of insulin in muscle?

1. increased glycogen synthesis

2. increased protein catabolism

3. decreased amino acid uptake

4. decreased ribosomal protein synthesis

5. decreased glucose entry into the cell

Figures

Answer (click for answer)

Preferred answer: 1

Discussion: Another simple question. The actions of insulin on muscle include increased glucose entry into cells, increased glycogen synthesis, increased amino acid uptake, increased ribosomal protein synthesis, decreased protein catabolism, and decreased release of gluconeogenic amino acids. The net result is anabolic as the muscle will store protein and carbohydrate and use glucose as the energy source. So answers #2, 3, 4, and 5 are wrong. See, simple!!

Reference: Buckwalter JA, Einhorn TA, Simon SR (eds): Orthopaedic Basic Science: Biology and Biomechanics of the Musculoskeletal System, ed 2. Rosemont, IL, American Academy of Orthopaedic Surgeons, 2000, pp683-716.