Clohisy Denis R. Metastatic Bone Disease: Future Directions. Clinical Orthopaedics and Related Research. 2003;415(Suppl):S95-S99. doi:10.1097/01.blo.0000093056.96273.b2.
Abstract
Bone cancer is common and difficult to treat. Current bone-targeted therapies include radiation and bisphosphonates. Both treatments can provide pain relief, but neither has been shown to prolong survival. Because bisphosphonates are osteoclast-targeted therapies, they do not exhibit significant tumor-killing properties in humans. Often, patients with asymptomatic skeletal metastases are treated with observation. New treatments are needed for patients known to have bone metastases and those who are at high risk for having bone metastases develop. Enzyme prodrug gene therapy treatment strategies currently are being explored for their potential benefit in designing novel therapies for bone cancer.
Last Updated on September 30, 2026
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OrthopaedicsOne Living Semantic Network🛠️ Operative Techniques
- Total scapular resections with endoprosthetic reconstruction Musculoskeletal Tumor
🩺 Clinical Conditions & Indications
- Who should undergo biopsy of a bone lesion Patient selection for a biopsy is important: It is intended to confirm the radiologic diagnosis in patients with...
- Who should do the biopsy of a bone lesion Clinical studies undertaken by the Musculoskeletal Tumor Society have documented a high incidence of problems suffered by patients...
- Where is the lesion Original Clinical Contribution: Authored for the OrthopaedicsOne Musculoskeletal Oncology Specialty Section. Preserved, digitized, and updated to modern evidence-based...
- What is the lesion doing to the bone Bone tumors have a limited number of potential effects on the skeleton. The most common is to produce...
🔬 Anatomy, Pathology & Diagnostics
- What kind of matrix is being made Generalized Bone and Joint
- Validation of cDNA Microarray Analysis to Distinguish Tumor Type Ex Vivo Generalized Bone and Joint
- Urokinase Plasminogen Activator System – A Multifunction Role in Tumour Progression and Metastasis Pelvis and Acetabulum
- Tumor Classifications Hip Joint & Proximal Femur