Cheng Edward Y. Prospective Quality of Life Research in Bony Metastatic Disease. Clinical Orthopaedics and Related Research. 2003;415:S289-S297. doi:10.1097/01.blo.0000093054.96273.20.
Abstract
Metastatic bone disease is a major factor contributing to the deterioration in quality of life in patients with cancer. The decision to surgically stabilize an impending or existing pathologic fracture, or to excise a metastatic deposit is difficult because of the paucity of conclusive data regarding the efficacy of surgery in achieving pain relief, improved function, and quality of life. The psychometric properties of quality of life outcomes instruments and the differences between pain, function, and quality of life are explored in an attempt to define surgical goals. The results of different quality of life instruments in existing studies of internal fixation, chemotherapy, radiation therapy, and bisphophonate treatment suggest that although the majority of patients derive benefit from their treatment, the success of such treatment is heavily dependent the quality of life instrument. Existing instruments are deficient and obstacles to the design and implementation of quality of life assessment in patients with skeletal metastasis are reviewed. Recommendations for improving our ability to assess the risk to benefit ratio of surgery include moving away from physician reported results, devising more appropriate quality of life measurement techniques, analyzing the relationship between pain relief, physical function and quality of life, and focusing attention on prospectively evaluating optimal treatments for patients as they near the end of life.
Last Updated on September 29, 2026
🔗 Knowledge Graph & Clinical Correlates
OrthopaedicsOne Living Semantic Network🛠️ Operative Techniques
- Total scapular resections with endoprosthetic reconstruction Musculoskeletal Tumor
🩺 Clinical Conditions & Indications
- Who should undergo biopsy of a bone lesion Patient selection for a biopsy is important: It is intended to confirm the radiologic diagnosis in patients with...
- Who should do the biopsy of a bone lesion Clinical studies undertaken by the Musculoskeletal Tumor Society have documented a high incidence of problems suffered by patients...
- Where is the lesion Original Clinical Contribution: Authored for the OrthopaedicsOne Musculoskeletal Oncology Specialty Section. Preserved, digitized, and updated to modern evidence-based...
- What is the lesion doing to the bone Bone tumors have a limited number of potential effects on the skeleton. The most common is to produce...
🔬 Anatomy, Pathology & Diagnostics
- What kind of matrix is being made Generalized Bone and Joint
- Validation of cDNA Microarray Analysis to Distinguish Tumor Type Ex Vivo Generalized Bone and Joint
- Urokinase Plasminogen Activator System – A Multifunction Role in Tumour Progression and Metastasis Pelvis and Acetabulum
- Tumor Classifications Hip Joint & Proximal Femur