Tumor biology
Rare, aggressive, malignant tumor
Gender
M:F = 2:1
Radiographic appearance
Confusing radiographic picture, with aggressive and nonaggressive features possible
Generally a cystic/lytic lesion, although indistinct margins may be seen
Site
Principally involves femur, tibia, and humerus at metaphyseal level
Tumor effect on bone
Most common pattern is lytic and expansile; may have a moth-eaten or permeative pattern (rare)
Periosteal reaction
May or may not be present
Soft tissue mass
Generally present, with hemorrhagic tumor extending into soft tissues
Differential diagnosis
Similar for all lytic expansile metaphyseal lesions
- Aneurysmal bone cyst
- Giant cell tumor
- Brown tumor
- Osteoblastoma
Pathology
Characterized by cystic, blood-filled channels lined by malignant tumor cells
Treatment
- Similar to conventional osteosarcoma
- Lesion responsive to chemotherapy
- Previous reports of particularly bad prognosis for this variant of osteosarcoma probably innaccurate
Last Updated on June 27, 2024
🔗 Knowledge Graph & Clinical Correlates
OrthopaedicsOne Living Semantic Network🛠️ Operative Techniques
- Total scapular resections with endoprosthetic reconstruction Musculoskeletal Tumor
🩺 Clinical Conditions & Indications
- Who should undergo biopsy of a bone lesion Patient selection for a biopsy is important: It is intended to confirm the radiologic diagnosis in patients with...
- Who should do the biopsy of a bone lesion Clinical studies undertaken by the Musculoskeletal Tumor Society have documented a high incidence of problems suffered by patients...
- Where is the lesion Original Clinical Contribution: Authored for the OrthopaedicsOne Musculoskeletal Oncology Specialty Section. Preserved, digitized, and updated to modern evidence-based...
- What is the lesion doing to the bone Bone tumors have a limited number of potential effects on the skeleton. The most common is to produce...
🔬 Anatomy, Pathology & Diagnostics
- What kind of matrix is being made Generalized Bone and Joint
- Validation of cDNA Microarray Analysis to Distinguish Tumor Type Ex Vivo Generalized Bone and Joint
- Urokinase Plasminogen Activator System – A Multifunction Role in Tumour Progression and Metastasis Pelvis and Acetabulum
- Tumor Classifications Hip Joint & Proximal Femur