Kelly Cynthia M., Wilkins Ross M., Eckardt Jeffrey J. et al. Treatment of Metastatic Disease of the Tibia. Clinical Orthopaedics and Related Research. 2003;415(Suppl):S219-S229. doi:10.1097/01.blo0000093843.72468.3a.
Abstract
Metastatic lesions to bone outnumber primary bone malignancies. Osseous metastases to the tibia tend to be less common than osseous metastases to other long bones. This study examined the treatment options for a population of patients with metastatic disease to the tibia, with surgical intervention being the cornerstone of treatment for the osseous lesion. A multicenter study had 592 patients with metastatic disease to the bone, with 26 lesions occurring in the tibia (4.4%) during a 13-year period. No patient had concurrent metastases distal to the elbow. After confirmation of metastatic disease, treatment consisted of surgical intervention in all patients, including plate osteosynthesis, intramedullary rodding and cementation, endoprosthetic replacement, and in most patients, postoperative radiation therapy. In 96% of patients, the reconstruction outlasted their life expectancy. All patients were satisfied with their reconstruction. Four complications were encountered in the postoperative period, all requiring additional surgery. Aggressive treatment of osseous metastasis is justified in patients with metastatic disease despite a limited life expectancy. Intervention by an orthopaedic oncologist may result in fewer reconstructive failures. Surgical intervention contributes to an improved quality of life and limb function, ease of nursing care, and may help in maintaining patient independence.
Last Updated on September 29, 2026
🔗 Knowledge Graph & Clinical Correlates
OrthopaedicsOne Living Semantic Network🛠️ Operative Techniques
- Upper Tibial Osteotomy Musculoskeletal Medicine
- Total scapular resections with endoprosthetic reconstruction Musculoskeletal Tumor
- Total Femur Arthroplasty Musculoskeletal Tumor
🧭 Surgical Approaches & Danger Zones
- Transfibular Approach Ankle Arthrodesis Tibia and Fibula
🩺 Clinical Conditions & Indications
- Who should undergo biopsy of a bone lesion Patient selection for a biopsy is important: It is intended to confirm the radiologic diagnosis in patients with...
- Who should do the biopsy of a bone lesion Clinical studies undertaken by the Musculoskeletal Tumor Society have documented a high incidence of problems suffered by patients...
- What is the lesion doing to the bone Bone tumors have a limited number of potential effects on the skeleton. The most common is to produce...
- Treatment of benign bone cysts Indications Discuss indications and more general concerns. Preoperative Planning Material to be reviewed and conditions to be addressed...
🔬 Anatomy, Pathology & Diagnostics
- Validation of cDNA Microarray Analysis to Distinguish Tumor Type Ex Vivo Hip Joint & Proximal Femur
- Urokinase Plasminogen Activator System – A Multifunction Role in Tumour Progression and Metastasis Hip Joint & Proximal Femur
- Treatment of Axial Skeleton Bone Metastases Lumbar Spine
- Transforming Growth Factor-Beta in Osteolytic Breast Cancer Bone Metastases Hip Joint & Proximal Femur