- Hypercoagulability secondary to activation of Factor X by thromboplastins from damaged tissue in association with stasis
- Secondary to use of a tourniquet or bandage and increased stickiness of platelets due to exposure of damaged tissue
- Prophylaxis indicated for prolonged bedridden or high risk patients
- Previous history of DVT
- Obese patients
- Patients with malignancy
- Patients on the oral contraceptive
- Following pelvic or hip fractures or operations
- Contraindicated if tend to bleed or have active peptic ulceration
- Treatment
- Commence once risk of bleeding reduced (72 hours) with subcutaneous heparin (LMW) 2500 units daily
- Commence Warfarin once risk of secondary bleed reduced (1 week to 10 days) and aim for INR around 2
