Workshop held in November 2003, manuscripts published inClinical Orthopaedics and Related Research® (CORR) in October 2004

Issue Table of Contents

The Classic – Commentaries on the History and Cure of Diseases. Digitorum Nodi

The Impact of Osteoarthritis – Implications for Research

Risk Factors for Osteoarthritis – Understanding Joint Vulnerability

Familial Inheritance of Osteoarthritis – Documented Family Subsets

The Role of Cytokines in Cartilage Matrix Degeneration in Osteoarthritis

The Regulation Chondrocyte Function by Proinflammatory Mediators – Prostaglandins and Nitric Oxide

Growth Factor Inhibition – Potential Role in the Etiopathogenesis of Osteoarthritis

Chemokines in Cartilage Degradation

Osteochondral Defect Repair by Demineralized Cortical Bone Matrix

The Mechanobiology of Articular Cartilage Development and Degeneration

Pathomechanic Determinants of Posttraumatic Arthritis

Pressure and Shear Differentially Alter Human Articular Chondrocyte Metabolism – A Review

Chondrocyte Senescence, Joint Loading and Osteoarthritis

Biology of Developmental and Regenerative Skeletogenesis

Collagens and Cartilage Matrix Homeostasis

Extracellular Matrix Gene Regulation

Novel Inhibitors of Matrix Metalloproteinase Gene Expression as Potential Therapies for Arthritis

Functional Genomics of Osteoarthritis – On the Way to Evaluate Disease Hypotheses

Protein Kinase in Chondrocyte Signaling and Osteoarthritis

Hyaluronan and CD44 – Modulators of Chondrocyte Metabolism

Up-regulation of Chondrocyte Matrix Genes and Products by Electric Fields

Toward Imaging Biomarkers for Osteoarthritis

Osteoarthritis – Current Treatment and Future Prospects for Surgical, Medical, and Biologic Interventions

Functional Tissue Engineering Parameters toward Designing Repair and Replacement Strategies