Workshop held in November 1997, manuscripts published as a supplement to the October 1998 issue ofClinical Orthopaedics and Related Research®(CORR)

Issue Table of Contents

Significant Advances Have Been Made in the Way Surgeons Treat Fractures

The Classic – A Case of Fracture of the Os Humeri, in which the Broken Ends of the Bone not Uniting in the Usual Manner, a Cure was Effected by Means of a Seton

The Cell and Molecular Biology of Fracture Healing

Concepts of Fracture Union, Delayed Union, and Nonunion

Pathophysiology of Delayed Healing

Mechanobiology of Skeletal Regeneration

Experimental Models of Fracture Repair

Initiation of Fracture Repair by Bone Morphogenetic Proteins

The Role of Osteochondral Progenitor Cells in Fracture Repair

Angiogenesis in Fracture Repair

Effects of Electromagnetic Fields in Experimental Fracture Repair

Strain Rate and Timing of Stimulation in Mechanical Modulation of Fracture Healing

Expression of Bone Morphogenetic Proteins in Fracture Healing

Transforming Growth Factor Beta in Fracture Repair

Effects of Mechanical Factors on the Fracture Healing Process

Potential Role for Gene Therapy in the Enhancement of Fracture Healing

Potential Role for Direct Gene Transfer in the Enhancement of Fracture Healing

Enhancement of Fracture Healing by Mechanical and Surgical Intervention

Mechanical Influences on Tibial Fracture Healing

Bone Regeneration and Fracture Healing. Experience with Distraction Osteogenesis Model

Clinical Effects of Electromagnetic and Electric Fields on Fracture Healing

Enhancement of Fracture Healing by Low Intensity Ultrasound

The Effect of Reamed and Nonreamed Intramedullary Nailing on Fracture Healing

Enhancement of Fracture Healing with Autogenous and Allogeneic Bone Grafts

Mesenchymal Stem Cells in Osteobiology and Applied Bone Regeneration

Clinical Use of Marrow Osteoprogenitor Cells to Stimulate Osteogenesis

Current Understanding of Osteoconduction in Bone Regeneration

Potential Role of Bone Morphogenetic Proteins in Fracture Healing

Potential Role of Fibroblast Growth Factor in Enhancement of Fracture Healing

The Potential Role of Transforming Growth Factor Beta in Fracture Healing

Potential Role of Insulinlike Growth Factors in Fracture Healing

Osteonecrosis of the Femoral Head. Potential Treatment with Growth and Differentiation Factors

Bone Repair and Enhancement Clinical Trial Design. Spine Applications

Proper Design of Clinical Trials for the Assessment of Bone Graft Substitutes

Breakout Session 1 – Definitions of Fracture Repair

Breakout Session 2 – Fracture Repair Process

Breakout Session 3 – Mechanical Enhancement of Callus Healing

Breakout Session 4 – Biophysical Enhancement

Breakout Session 5 – Biologic Enhancement of Fracture Repair

Breakout Session 6 – Regional Gene Therapy