Workshop held in November 2002, manuscripts published as a supplement to the October 2003 issue ofClinical Orthopaedics and Related Research®(CORR)

Issue Table of Contents

The Classic – Metastatic Disease in Long Bones – A Proposed Scoring System for Diagnosing Impending Pathologic Fractures

Advances and Challenges in the Surgical Treatment of Metastatic Bone Disease

The Molecular Basis of Skeletal Metastases

Transforming Growth Factor-Beta in Osteolytic Breast Cancer Bone Metastases

Breast Cancer Metastasis to Bone – It Is Not All About PTHrP

Urokinase Plasminogen Activator System – A Multifunction Role in Tumour Progression and Metastasis

The Mevalonate Synthesis Pathway as a Therapeutic Target in Cancer

Mechanisms of Osteoblastic Metastases – Role of Endothelin-1

NFkappaB – A Pivotal Transcription Factor in Prostate Cancer Metastasis to Bone

Renal Cell Carcinoma Bone Metastasis – Epidermal Growth Factor

Metastatic Bone Disease – Future Directions

Molecular Mechanisms of Bone Metastasis and Therapeutic Implications

Evaluation of the Patient with Carcinoma of Unknown Origin Metastatic to Bone

Validation of cDNA Microarray Analysis to Distinguish Tumor Type Ex Vivo

Diagnosis of Occult Bone Metastases – Positron Emission Tomography

Presentation and Staging of Metastatic Bone Disease

Metastatic Breast Cancer – Overview of Treatment

Biochemical Markers and Skeletal Metastases

Prostate Cancer and Bone Metastases – Medical Treatment

General Principles of External Beam Radiation Therapy for Skeletal Metastases

Metastatic Disease of the Spine – Evaluation and Treatment

Vertebroplasty and Kyphoplasty for Osteolytic Vertebral Collapse

Acetabular Metastases – Planning for Reconstruction and Review of Results

Treatment of Axial Skeleton Bone Metastases

Critical Evaluation of Mirels’ Rating System for Impending Pathologic Fracture

Risk of Pathologic Fracture – Assessment

Evaluation and Treatment of Metastases to the Humerus

Treatment of Metastatic Disease of the Tibia

Metastatic Disease of the Femur – Surgical Treatment

Cardiopulmonary Complications of Intramedullary Fixation of Long Bone Metastases

Endoprosthetic Reconstructions for Bone Metastases

PMMA to Stabilize Bone and Deliver Antineoplastic and Antiresorptive Agents

Operative Treatment of Long Bone Metastases – Focus on the Femur

Bone Cancer Pain

Prospective Quality of Life Research in Bony Metastatic Disease