Autosomal-dominant disorder characterized by a tetrad of abnormal growths

  • Osteomas
  • Intestinal polyposis of small and large bowel
  • Fibromas of soft tissue
  • Sebaceous cysts of skin

Disorders associated with Gardner’s Syndrome

  • Fibrosarcoma
  • Dental abnormalities
  • Carcinoma of the ampulla of Vater
  • Thyroid carcinoma
  • Colon cancer (develops in ALL untreated cases)

Bony tumors usually precede other manifestations and continue to develop, regardless of other lesions