Autosomal-dominant disorder characterized by a tetrad of abnormal growths
- Osteomas
- Intestinal polyposis of small and large bowel
- Fibromas of soft tissue
- Sebaceous cysts of skin
Disorders associated with Gardner’s Syndrome
- Fibrosarcoma
- Dental abnormalities
- Carcinoma of the ampulla of Vater
- Thyroid carcinoma
- Colon cancer (develops in ALL untreated cases)
Bony tumors usually precede other manifestations and continue to develop, regardless of other lesions