Nishida Kotaro, Gilbertson Lars G., Robbins Paul D. et al. Potential Applications of Gene Therapy to the Treatment of Intervertebral Disc Disorders. Clinical Orthopaedics and Related Research. 2000;379(Suppl):S234-S241. doi:10.1097/00003086-200010001-00031.
Abstract
Gene therapy involves the transfer of genes to cells such that the recipient cells express these genes and thereby synthesize the ribonucleic acid and protein that they encode. Recent investigations suggest that gene therapy may have potential applications in the treatment of intervertebral disc disorders, particularly those associated with disc degeneration. The successful in vivo transfer of therapeutic genes to target cells within the intervertebral disc in clinically relevant animal models is one example of the rapid progress that is being made. The purpose of the current review is to address several important technical issues, including choice of vectors and gene delivery strategy and the characteristics of the target tissues, which are relevant to future clinical applications of gene therapy for the treatment of intervertebral disc disorders. It already is apparent from the growing literature that gene therapy has the potential of becoming a valuable clinical treatment mode for intervertebral disc disorders in the twenty-first century.
Last Updated on September 29, 2026
🔗 Knowledge Graph & Clinical Correlates
OrthopaedicsOne Living Semantic Network🛠️ Operative Techniques
🩺 Clinical Conditions & Indications
- Torts 1. High-Yield Summary Medical tort liability in orthopaedic surgery arises when clinical care departs from accepted standards of...
- Timing of secondary sexual characteristics 1. High-Yield Overview & Clinical Purpose Biological Staging and Pubertal Timing: Secondary sexual characteristics, categorized via the Marshall...
- Thoracolumbar trauma Introduction Trauma to the lumbar or thoracic spine remains a clinical challenge from a diagnostic and management perspective....
- Thoracolumbar sprains 1. High-Yield Summary Definition & Core Distinction: Thoracolumbar sprains involve mechanical injury, micro-tearing, or partial disruption of the...
🔬 Anatomy, Pathology & Diagnostics
- Vertebroplasty and Kyphoplasty for Osteolytic Vertebral Collapse Lumbar Spine
- Vertebral endplate and marrow changes – Modic classification Lumbar Spine
- Vertebra prominens Surface Anatomy Lumbar Spine
- Tumbling Bullet Sign Lumbar Spine